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Products 11(beta)-Hydroxysteroid Dehydrogenase (Type 2) Polyclonal Antibody
| Catalogue number: | 10004549 |
| Hosts: | Rabbit |
| Applications: | Western Blot |
| Weight: | 0 |
| Form: | 1 ea |
| Antigen: | human 11.beta.-Hydroxysteroid dehydrogenase (Type 2) (11.beta.-HSD2) amino acids 25-40 (RSDLRLGRPLLAALAL) |
| P type: | Antibodies |
| Shipping temp: | -20 |
| Storage temp: | -20 |
| Additional info: | 11(beta)-HSD2 plays a critical role in normal physiology in the corticosteroid regulation of sodium homeostasis and the pathophysiology of hypertension by converting active cortisol to inactive cortisone. Mutation in the gene encoding 11(beta)-HSD2 results in cortisol induction of hypertension and hypokalemia, a syndrome of apparent mineralocorticoid excess. 11(beta)-HSD2 mRNA and protein are expressed in placenta and mineralocorticoid target tissues, particularly the kidney. In mouse, expression of this enzyme is tissue-specific and developmentally regulated, indicating the importance of the enzyme in controlling glucocorticoid-mediated maturation. Cayman's 11(beta)-HSD2 polyclonal antibody can be used for western blotting and immunochemical analysis of 11(beta)-HSD2 from samples of human, rat, and mouse. The antibody detects a band at 44 kDa in tissues such as kidney and cell lines including Caco-2 cells and HT-29 cells. |
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