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4-1BB LIGAND (TNFSF9, 4-1BBL, 4-1BB-L, Tumor necrosis factor ligand superfamily member 9)

Cat no: 0004-01H


Supplier: United States Biological
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TNFSF9, a type II transmembrane glycoprotein and member of the TNF superfamily, preferentially expressed by B cells, which acts as a ligand for CD137 (4-1BB ligand receptor/TNFRSF9). Interaction between 4-1BBL and its receptor acts as a co-stimulatory signal for T cell activation and expansion, and is involved in the generation of cytotoxic T cells (Tc) and in the process of antigen presentation. Expression of 4-1BBL by a variety of carcinoma cells, suggests a role for 4-1BBL in tumor cell-T cell interactions. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 0.5-2ug/ml Western Blot: 0.1-0.2ug/ml Optimal dilutions to be determined by the researcher. Recommended Secondary Antibodies: Goat Anti Rabbit IgG (H&L) HRP Sheep Anti Rabbit IgG Biotin Goat Anti Rabbit IgG (Fc) FITC, HRP Goat Anti Rabbit IgG (H&L) HRP Sheep Anti Rabbit IgG FITC Sheep Anti Rabbit IgG RPE Sheep Anti Rabbit IgG DyLight(TM)488, DyLight(TM)549, DyLight(TM)649 Sheep Anti Rabbit IgG HRP Storage and Stability: Lyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with sterile 100ul dH2O. Aliquot and store at -20 degrees C. Reconstituted product is stable for 12 months at -20 degrees C. For long term storage the addition of 0.09% sodium azide is recommended. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: 0004-01H
Reactivities: Human
Hosts: Rabbit
Applications: ELISA, Western Blot
Size: 100ug
Form: Supplied as a lyophilized powder in PBS, pH 7.2. Reconstitute in 100ul distilled water.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
Additional info: Recognizes human 4-1BB Ligand, otherwise known as TNFSF9

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