Home  >  Products  >  A-769662 (6,7-Dihydro-4-hydroxy-3-(2'-hydroxy[1,1'-biphenyl]-4-yl)-6-oxo-thieno[2,3-b]pyridine-5-carbonitrile)
A-769662 (6,7-Dihydro-4-hydroxy-3-(2'-hydroxy[1,1'-biphenyl]-4-yl)-6-oxo-thieno[2,3-b]pyridine-5-carbonitrile)

A-769662 (6,7-Dihydro-4-hydroxy-3-(2'-hydroxy[1,1'-biphenyl]-4-yl)-6-oxo-thieno[2,3-b]pyridine-5-carbonitrile)

Cat no: A0001-68U

Supplier: United States Biological
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A-769662 is a potent, reversible activator of AMP-activated protein kinase (AMPK). AMPK is an alpha beta gamma heterotrimer and plays an important role in regulating cellular and whole-body metabolism. A-769662 only activates AMPK heterotrimers containing the B1 subunit. A-769662 activates AMPK through the beta subunit carbohydrate-binding module and the gamma subunit but not the AMP-binding sites. Solubility: Soluble in DMSO at 33mg/ml; soluble in ethanol at 5mg/ml with slight warming; very poorly soluble in water; maximum solubility in plain water is estimated to be about 50-100uM; buffers, serum, or other additives may increase or decrease the aqueous solubility. Melting Point: 277-280C Elemental Analysis: Calculated C: 64.25% H: 3.64% N: 7.49% S: 8.58% Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at -20 degrees C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Catalogue number: A0001-68U
Size: 10mg
Form: Supplied as an off-white powder.
Purity: ~99%
References: 1. Scott, J.W., et al. "Thienopyridone drugs are selective activators of AMP-activated protein kinase b1-containing complexes." Chem. Biol. 15:1220-1230 (2008). 2. Cool, B., et al. "Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome." Cell Metab. 3:403-416 (2006). 3. Sanders, M.J., et al. "Defining the mechanism of activation of AMP-activated protein kinase by the small molecule A-769662, a member of the thienopyridone family." J. Biol. Chem. 282:32539-32548 (2007). 4. G

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