Alpha 1 acid glycoprotein (alpha 1-AGP), also known as orosomucoid (ORM1), is a 40kDa major acute phase reactant secreted into the plasma by the liver, believed to act as an anti-inflammatory and immunomodulatory agent. An increase in plasma alpha 1-AGP levels occurs during tissue injury, inflammation, infection, surgery, acute myocardial infarction, trauma and pregnancy. Regulators of alpha 1-AGP expression include IL-1beta, IL-6, glucocorticoids, TNF-alpha and retinoic acids, and alpha 1-AGP can bind to drugs from endogenous and exogenous origin.
Applications:
Suitable for use in Turbidimetry. Other applications not tested.
Recommended Dilution:
Optimal dilutions to be determined by the researcher.
Recommended Secondary Antibodies:
I1904-28K: IgG, H&L (HRP) Pab RbxGt
I1904-28Q: IgG, H&L, X-Adsorbed (HRP) Pab RbxGt
Storage and Stability:
May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
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