Home  >  Products  >  AcCoA Acetyltransferase (ACAT, Acetoacetyl CoA Thiolase, Acetyl CoA Acetyltransferase Mitochondrial, Acetyl Coenzyme A Acetyltransferase 1, ACAT1, MAT, RATACAL, T2, THIL)
AcCoA Acetyltransferase (ACAT, Acetoacetyl CoA Thiolase, Acetyl CoA Acetyltransferase Mitochondrial, Acetyl Coenzyme A Acetyltransferase 1, ACAT1, MAT, RATACAL, T2, THIL)

AcCoA Acetyltransferase (ACAT, Acetoacetyl CoA Thiolase, Acetyl CoA Acetyltransferase Mitochondrial, Acetyl Coenzyme A Acetyltransferase 1, ACAT1, MAT, RATACAL, T2, THIL)

Cat no: A0220-01J

Supplier: United States Biological
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Acely-CoA:cholestorl acyltransferase (ACAT) is an integral membrane enzyme that belongs to type-B carboxylesterase/lipase family. ACAT catalyzes the formation of cholesteryl esters from cholesterol and long-chain fatty-acyl-coenzyme A (1). ACAT also function as a regulator of intracellular cholesterol homeostasis at single cell level. Two isoform of ACAT exists, ACAT1 and ACAT2, are expressed in liver and intestine. However, ACAT1 is only found in macrophages and SMCs (2). The accumulation of cholesteryl esters produced by ACAT in macrophages can lead to foam cell formation, an indication of early stage atherosclerosis. ACAT activity has been linked to Alzehimer
Catalogue number: A0220-01J
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Immunocytochemistry, Immunohistochemistry, Western Blot
Size: 100ul
Form: Supplied as a liquid in 50 mM Tris-Glycine (pH 7.4), 0.15 M sodium chloride, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Buhman KF et al. Biochim Biophys Acta 1529(1-3): 142-54, 2000 2. Puglielli L et al. Nat Cell Biol 3(10) 905-12, 2001. 3. Chang C et al. Acta Biochim Biophys Sin 38(3): 151-156, 2006.
Additional info: Recognizes human ACAT. Species Crossreactivity: Mouse and rat

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