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Acetyl CoA Carboxylase 1 (ACAC, ACC, ACC1, ACCA, ACC-alpha, Acetyl-CoA carboxylase alpha)

Acetyl CoA Carboxylase 1 (ACAC, ACC, ACC1, ACCA, ACC-alpha, Acetyl-CoA carboxylase alpha)

Cat no: A0224-02D

Supplier: United States Biological
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Acetyl-CoA carboxylase (ACC) catalyzes the pivotal step of the fatty acid synthesis pathway. The 265kD ACCalpha (ACC1) is the predominant isoform found in liver, adipocytes and mammary gland, while the 280kD ACCbeta (ACC2) is the major isoform in skeletal muscle and heart (1). Phosphorylation by AMPK at Ser79 or by PKA at Ser1200 inhibits the enzymatic activity of ACC (2). ACC is a potential target of anti-obesity drugs (3,4). Applications: Suitable for use in Western Blot, Immunofluorescence, and Immunoprecipitation. Other applications not tested. Recommended Dilution: Western Blot: 1:1000 Incubate membrane with diluted antibody in 5% BSA, 1X TBS, 0.1% Tween-20 at 4 degrees C with gentle shaking, overnight. Immunofluorescence (IC): 1:800 Immunoprecipitation: 1:50 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: A0224-02D
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Immunofluorescence, Immunoprecipitation, Western Blot
Size: 100ul
Form: Supplied as a liquid in 10mM sodium HEPES pH 7.5, 150mM sodium chloride, 0.1mg/ml BSA and 50% glycerol.
P type: Pab
Isotype: IgG
Purity: Purified by Protein A and peptide affinity chromatography.
References: 1. Ruderman, N.B. et al. (1999) Am. J. Physiol. 276, E1-E18, 2. Ha, J. et al. (1994) J. Biol. Chem. 269, 22162-22168, 3. Abu-Elheiga, L. et al. (2001) Science 291, 2613-2616, 4. Levert, K.L. et al. (2002) J. Biol. Chem. 277.
Additional info: Recongnizes endogenous levels of human total Acetyl CoA Carboxylase 1 protein. Species crossreactivity: mouse and rat.

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