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Acid Sensitive Ion Channel 2b (ASIC2B, MDEG2 Mammalian Degenerin2)

Acid Sensitive Ion Channel 2b (ASIC2B, MDEG2 Mammalian Degenerin2)

Cat no: A0574-02B

Supplier: United States Biological
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Tissue acidosis that occurs in ischemia, tissue damage or inflammation is accompanied by pain. Proton-gated cation channels are activated by low pH in nociceptive neurons. H+-gated channels are members of the NaC/DEG superfamily that include: (1) Amiloride-sensitive epithelial Na+ channels (a, b, g, and d-ENaC subunits); (2) A FMRFamide-gated channel (FaNaC); (3) mechanosensory channel proteins of nematode degenerins (DEG). NaC/DEG superfamily is characterized by intracellular N and C-termini, two transmembrane domains, and a large extracellular loop. All members of this family are selective for Na+ and blocked by amiloride. Applications: Suitable for use in Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry: 1:300-1:3000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: A0574-02B
Reactivities: Human, Rat
Hosts: Rabbit
Applications: Immunohistochemistry
Size: 100ul
Form: Supplied as a liquid in PBS, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Lingueglia, E., et al. (1997) J. Biol. Chem. 272: 29778-29783. 2. Waldmann, R., et al. (1999) Ann. NY Acad. Sci. 869: 67-75.
Additional info: Recognizes human Acid Sensitive Ion Channel 2b. Species Crossreactivity: rat.

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