Home  >  Products  >  Aconitase 1 (ACO1, ACONS, IREB1, IREBP, IREBP1, IRP1, OTTHUMP00000021176, OTTHUMP00000021177, OTTHUMP00000045233, aconitate hydratase, citrate hydro-lyase, ferritin repressor protein, iron regulatory protein 1, iron-responsive element binding protein 1)
Aconitase 1 (ACO1, ACONS, IREB1, IREBP, IREBP1, IRP1, OTTHUMP00000021176, OTTHUMP00000021177, OTTHUMP00000045233, aconitate hydratase, citrate hydro-lyase, ferritin repressor protein, iron regulatory protein 1, iron-responsive element binding protein 1)

Aconitase 1 (ACO1, ACONS, IREB1, IREBP, IREBP1, IRP1, OTTHUMP00000021176, OTTHUMP00000021177, OTTHUMP00000045233, aconitate hydratase, citrate hydro-lyase, ferritin repressor protein, iron regulatory protein 1, iron-responsive element binding protein 1)

Cat no: A0660-01D

Supplier: United States Biological
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Aconitase (aconitate hydratase; EC 4.2.1.3) is an iron-sulfur protein containing an [Fe4S4]2+ cluster that catalyzes the stereospecific isomerization of citrate to isocitrate via cis-aconitate in the tricarboxylic acid cycle, a non-redox-active process. Tissue contains two aconitases, a mitochondrial (m-) and a cytosolic (c-) aconitase. They are related, but distinctly different enzymes and are coded for on different chromosomes. Loss of aconitase activity in cells or other biological samples treated with pro-oxidants has been interpreted as a measure of oxidative damage. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:8000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: A0660-01D
Reactivities: Human
Hosts: Goat
Applications: Western Blot
Size: 100ug
Form: Supplied as a liquid in Tris saline, 0.02% sodium azide, pH7.3, 0.5% BSA.
P type: Pab
Isotype: IgG
Purity: Purified by affinity chromatography.
References: 1. Wang W, Di X, D'Agostino RB, Torti SV, Torti FM, Excess capacity of the iron regulatory protein system. The Journal of biological chemistry 2007 Aug 282 (34): 24650-9.
Additional info: Recognizes human Aco1/Aconitase 1. Sequence homology: mouse, rat, bovine.

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