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Acrosin (Acrosin Precursor, ACRS, ACR, 53kD Fucose-binding Protein)

Acrosin (Acrosin Precursor, ACRS, ACR, 53kD Fucose-binding Protein)

Cat no: A0700-75

Supplier: United States Biological
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ACR is the major proteinase present in the acrosome of mature spermatozoa. It is a typical serine proteinase with trypsin-like specificity. It is stored in the acrosome in its precursor form, proacrosin. The active enzyme functions in the lysis of the zona pellucida, thus facilitating penetration of the sperm through the innermost glycoprotein layers of the ovum. The mRNA for proacrosin is synthesized only in the postmeiotic stages of spermatogenesis. In humans proacrosin first appears in the haploid spermatids. Applications: Suitable for use in Immunocytochemistry and Western Blot. Other applications not tested. Recommended Dilution: Immunocytochemistry: 1:10 Membrane permeabilization with acetone is essential. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: A0700-75
Reactivities: Porcine
Hosts: Mouse
Applications: Immunocytochemistry, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, pH 7.4, 15mM sodium azide.
P type: Mab
Isotype: IgG1
Purity: Purified by Protein A affinity chromatography.
Alternative names: EC=3.4.21.10
References: 1. Peknicova, P., and Moos, J., 1990, Andrologica 22, 427-435. 2. Moos J. et al., 1993 Biol. Reprod. 49, 408. 3. Peknicova, P., et al., 1994, Anim. Reprod. Sci, 35, 255.
Additional info: Recognizes various forms of porcine acrosin (55, 53, 45 and 35kD) in the acrosome of undamaged spermatozoa. Does not cross react with human, bull or canine sperms.

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