Home  >  Products  >  ACSL5 (A-CoA Synthetase Long-chain Family Member 5, HGNC:16526, ACS2, ACS5, FACL5, Fatty-acid-Coenzyme A Ligase, Long-chain 5, Long-chain Acyl-CoA Synthetase 5)
ACSL5 (A-CoA Synthetase Long-chain Family Member 5, HGNC:16526, ACS2, ACS5, FACL5, Fatty-acid-Coenzyme A Ligase, Long-chain 5, Long-chain Acyl-CoA Synthetase 5)

ACSL5 (A-CoA Synthetase Long-chain Family Member 5, HGNC:16526, ACS2, ACS5, FACL5, Fatty-acid-Coenzyme A Ligase, Long-chain 5, Long-chain Acyl-CoA Synthetase 5)

Cat no: A0196-01

Supplier: United States Biological
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The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in uterus and spleen, and in trace amounts in normal brain, but has markedly increased levels in malignant gliomas. This gene functions in mediating fatty acid-induced glioma cell growth. Three transcript variants encoding two different isoforms have been found for this gene. Positive Control: Human Spleen lysate Applications: Suitable for use in ELISA (peptide) and Western Blot. Other applications not tested. Recommended Dilution: ELISA (peptide): 1:16,000 Western Blot: 1-3ug/ml. ~ 75kD band observed in Human Spleen lysates (calculated MW of 76.0kD according to NP_976313.1and NP_976314.1). Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: A0196-01
Reactivities: Human
Hosts: Goat
Applications: ELISA, Western Blot
Size: 100ug
Form: Supplied as a liquid in Tris-saline, pH 7.2. 0.5% BSA, 0.02% sodium azide.
P type: Pab
Purity: Purified by immunoaffinity chromatography.
References: Obermuller N, Keith M, Kopitz J, Autschbach F, Schirmacher P, Gassler N. Coeliac disease is associated with impaired expression of acyl-CoA-synthetase 5.Int J Colorectal Dis. 2005 Apr 5; [Epub ahead of print] PMID: 1580983
Additional info: Species Crossreactivity: Human. Other species not tested.

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