Home  >  Products  >  Actin, alpha, Smooth Muscle (Actin, Aortic Smooth Muscle, Alpha-actin-2, Cell Growth-inhibiting Gene 46 Protein, ACTA2, ACTSA, ACTVS, GIG46)
Actin, alpha, Smooth Muscle (Actin, Aortic Smooth Muscle, Alpha-actin-2, Cell Growth-inhibiting Gene 46 Protein, ACTA2, ACTSA, ACTVS, GIG46)

Actin, alpha, Smooth Muscle (Actin, Aortic Smooth Muscle, Alpha-actin-2, Cell Growth-inhibiting Gene 46 Protein, ACTA2, ACTSA, ACTVS, GIG46)

Cat no: A0760-26V

Supplier: United States Biological
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Actins are highly conserved proteins expressed in all eucaryotic cells. Actin filaments form part of the cytoskeleton and play essential roles in regulating cell shape and movement. Six distinct actin isotypes have been identified in mammalian cells. Each is encoded by a separated gene and is expressed in a developmentally regulated and tissue- specific manner, alpha and beta-cytoplasmic actins are expressed in a wide variety of cells; whereas, expression of a- skeletal, a-cardiac, a-vascular, and gamma enteric actins are more restricted to specialized muscle cell type. Smooth muscle a-actin is of further interest because it is one of a few genes whose expression is relatively restricted to vascular smooth muscle cells. Further more, expression of smooth muscle a-actin is regulated by hormones, cell proliferation, and altered by pathological conditions including oncogenic transformation and atherosclerosis. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 0.5-2ug/ml Immunohistochemistry: 1:50-1:200 for 10min Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: A0760-26V
Reactivities: Human, Mouse
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 50ug
Form: Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Buckingham, M. et al. Adv Exp Med 182, 333 (1985). 2. Reddy, S. et al. J Biol Chem 265, 18683 (1990). 3. Hsu, C-Y et al. J Biol Chem 262, 9594 (1987). 4. Owens, G. et al. J Cell Biol 102, 343 (1988). 5. Leavitt, J. et al. Nature 316, 840 (1985). 6. Gabbiani, G. et al. J Clin Invest 73, 148 (1984). 7. Skalli, O. et al. J Cell Biol 103, 2787 (1986).
Additional info: Recognizes actin from human smooth muscle. Species Crossreactivity: mouse.

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