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Actin, Smooth Muscle

Actin, Smooth Muscle

Cat no: A0760-31A

Supplier: United States Biological
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Actin is a major component of the cytoskeleton and is present in every cell type. Actin can be resolved on the basis of its isoelectric points into three distinctive components: alpha, beta, and gamma in order of increasing isoelectric point. Smooth Muscle Actin Ab does not stain cardiac or skeletal muscle, however, it will stain myofibroblasts and myoepithelial cells. This antibody could be used together with Muscle Specific Actin to distinguish leiomyosarcoma from rhabdomyosarcoma. In most cases of rhabdomyosarcoma, this antibody gives negative results whereas M. S. Actin is positive in the rhabdomyoblasts. Leiomyosarcomas are positive with both M. S. Actin and S. M. Actin antibodies. Applications: Suitable for use in Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry (Paraffin, frozen): 1:10-1:50 Required Heat Induced Epitope Retrieval (HIER) for paraffin. Optimal dilutions to be determined by the researcher. Positive Control: Appendix, Uterus, Vessel Wall Staining Pattern: Cytoplasmic Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: A0760-31A
Reactivities: Human
Hosts: Mouse
Applications: ELISA, Immunohistochemistry
Size: 1ml
Form: Supplied as a liquid in PBS, pH 7.4, 1% BSA, <0.1% sodium azide.
P type: Mab
Isotype: IgG,k
Purity: Ascites
References: 1. Cooke, PH., J Cell Biol. 1976; 68-539-556 2. Skalli, O., et al., J Cell Biol. 1986; 103:2787-2796 3. Gown, AM. et al., J Cell Biol. 1985; 100:807-813 4. Kuroda, M., Biochem Biophys Acta 1985; 843:20-213 5. Lazarides, E., J Histochem Cytochem 1975; 223:507-528.
Additional info: Recognizes human Actin, Smooth Muscle.

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