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Akt1 (phospho Ser246) Polyclonal Antibody

Cat no: ABP50255


Supplier: Abbkine Scientific Co.Ltd.
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The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in AKT1 have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for AKT1.
Catalogue number: ABP50255
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: ELISA, Immunofluorescence, Immunohistochemistry - fixed, Western Blot
Size: 30micro l, 100micro l, 200micro l
Accession: P31749
Gene: 207
Concentration: 1 mg/ml
Isotype: Rabbit IgG
Clonality: Polyclonal

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