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BK Beta4, S18A-3

BK Beta4, S18A-3

Cat no: SMC-384D


Supplier: StressMarq Biosciences Inc.
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Detects ~24kDa.
Catalogue number: SMC-384D
Reactivities: Human, Mouse
Hosts: Mouse
Applications: Immunohistochemistry, Immunoprecipitation, Western Blot
Size: 100ug
Clone: S18A-3
Dilutions: 1ug/mL (WB), 0.1-1ug/mL (IHC/ICC), 1-10ug/mL (IF)
Form: Protein G Purified
Storage buffer: PBS pH7.4, 50% glycerol
Concentration: 1mg/mL
Isotype: IgG2A
Shipping temp: Blue Ice or 4
Storage temp: -20
Research area: Ion Channels
Certificate of analysis: 1 ug/mL of SMC-384 was sufficient for detection of BK Channel beta4 in 10ug of COS-1 cells transiently transfected with KBeta2 lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Scientific background: BK channels contribute to electrical impulses, proper signal transmission of information and regulation of neurotransmitter release (3). A gain of function mutation in the pore-forming alpha subunit of the BK channel was linked to human neurological disea
References: 1. Hille B. (2001) Ion Channels of Excitable Membranes, 3rd Ed., Sinauer Associated Inc.: Sunderland, MA USA 2. www.iochannels.org 3. Wulf-Johansson H., et al. (2009) Brain Res. 1292: 1-13. 4. Lee U.S., and Cui J. (2009) J Physiol. 587(7): 1481-1489.
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