BMPs (bone morphogenetic proteins) belong to the TGF-b superfamily of structurally related signaling proteins. As implied by their name, BMPs promote and regulate bone development, growth, remodeling and repair, in both prenatal development and postnatal growth of eye, heart, kidney, skin, and other tissues. In addition to its osteogenic activity, BMP-2 also plays an important role in cardiac morphogenesis. BMP-2 is expressed in a variety of tissues such as lung, spleen, brain, liver, prostate ovary, and small intestine. Recombinant human BMP-2 is a 26kD homodimeric protein consisting of two 115aa polypeptide chains.
Source:
Recombinant protein corresponding to human BMP2 at expressed in E.coli.
Molecular Weight:
~26kD
Biological Activity:
The ED50 as determined by the dose-dependent cytolysis of MC3T3-E1 cells is <50ng/ml.
Endotoxin:
~0.1ng/ug
Storage and Stability:
Lyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Reconstituted product is stable for 6 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
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