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Products Borrelidin (Treponemycin, Antibiotic U 78548, Antibiotic C2989)
| Catalogue number: | B2570-28 |
| Size: | 500ug |
| Purity: | >99% by HPLC |
| Alternative names: | Treponemycin, Antibiotic U 78548, Antibiotic C2989 |
| References: | 1. A unique hydrophobic cluster near the active site contributes to differences in borrelidin inhibition among threonyl-tRNA synthetases. Ruan T. et al. J. Biol. Chem. 2005, 280, 571. 2. Borrelidin is an angiogenesis inhibitor; disruption of angiogenic capillary vessels in a rat aorta matrix culture model. Wakabayashi T. et al. J. Antibiot. 1997, 50, 671. 3. Anti-angiogenesis effects of borrelidin are mediated through distinct pathways: threonyl-tRNA synthetase and caspases are independently involved in suppression of proliferation and induction of apoptosis in endothelial cells. Kawamura T. et al. J. Antibiot. 2003, 56, 709. 4. In vitro and in vivo antimalarial activities of a non-glycosidic 18-membered macrolide antibiotic, borrelidin, against drug-resistant strains of Plasmodia. Otoguro K. et al. J. Antibiot. 2003, 56, 727. |
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