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c-Myc (phospho Thr58) Polyclonal Antibody

c-Myc (phospho Thr58) Polyclonal Antibody

Cat no: ABP50291

Supplier: Abbkine Scientific Co.Ltd.
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V-myc avian myelocytomatosis viral oncogene homolog encoded by MYC is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of MYC.
Catalogue number: ABP50291
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: ELISA, Immunohistochemistry - fixed, Immunoprecipitation, Western Blot
Size: 30micro l, 100micro l, 200micro l
Accession: P01106
Gene: 4609
Concentration: 1 mg/ml
Isotype: Rabbit IgG
Clonality: Polyclonal

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