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Calphostin C (Antibiotic UCN-1028 C, UCN 1028 C)

Cat no: C1035-38


Supplier: United States Biological
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Calphostin C is a perylenequinione isolated from the fungus, Cladosporium cladosporioides. It is a potent and specific inhibitor of protein kinase C with inhibition being light dependent. Also shown to inhibit cell proliferation and induce apoptosis in vitro. Purity: >95% by HPLC Solubility: Soluble in ethanol, methanol, DMF or DMSO
Catalogue number: C1035-38
Size: 100ug
Purity: : >95% by HPLC
Alternative names: Antibiotic UCN-1028 C, UCN 1028 C
References: 1. Growth inhibition induced by Ro 31-8220 and calphostin C in human glioblastoma cell lines is associated with apoptosis and inhibition of CDC2 kinase. Begemann M. et al. Anticancer Res. 1998, 18, 3139. 2. Inhibition of protein kinase C by calphostin C is light-dependent. Bruns R.F. et al. Biochem. Biophys. Res. Commun. 1991, 176, 288. 3. Calphostins (UCN-1028), novel and specific inhibitors of protein kinase C. I. Fermentation, isolation, physico-chemical properties and biological activities. Kobayashi E. et al. J. Antibiot. 1989, 42, 1470. 4. Calphostins, novel and specific inhibitors of protein kinase C. II. Chemical structures. Kobayashi E. et al. J. Antibiot. 1989, 42, 1475.

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