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Products CD36 Monoclonal Antibody (Clone JC63.1) (azide free)
| Catalogue number: | 10009893 |
| Hosts: | Mouse |
| Applications: | Flow Cytometry, Immunocytochemistry |
| Weight: | 0 |
| Form: | 1 ea |
| Antigen: | recombinant adenovirus expressing full-length mouse CD36 |
| P type: | Antibodies |
| Shipping temp: | 4 |
| Storage temp: | 4 |
| Additional info: | CD36 is a type-B scavenger receptor that is necessary for the formation of foam cells and thereby atherosclerotic lesions. This membrane glycoprotein can internalize fatty acids which activate PPAR(gamma) and stimulate further expression of CD36. This positive feedback loop combined with the murine CD36 knock-out studies reinforces the importance of CD36 in lipid metabolism. Additionally, CD36 is needed for the phagocytosis of P. falciparum infected erythrocytes, retinal pigment epithelial cell photoreceptor fragments and post-apoptotic monocytes and neutrophils. CD36 expression has been monitored during hematopoietic cell differentiation and may be an indicator of tumor spreading in lymphocytic leukemia. Positive controls include adipose and heart tissue, platelets, and macrophages. |
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