Cefoperazone is a third generation cephalosporin antibiotic. Cefoperazone exerts its bactericidal effect by inhibiting the bacterial cell wall synthesis, and sulbactam acts as a beta-lactamase inhibitor, to increase the antibacterial activity of cefoperazone against beta-lactamase producing organisms. It is one of few cephalosporin antibiotics effective in treating Pseudomonas bacterial infections which are otherwise resistant to these antibiotics.
Melting Point:
178-180C
Solubility:
Water, Methanol (heated)
Atmosphere:
Inert Gas
Method for Determining Identity:
Proton NMR (D2O) Spectroscopic and Mass Spectrometric Analysis
TLC Conditions:
C18; Acetonitrile: Water: Ammonium Hydroxide; 8: 2: 0.2: Visualized with UV and AMCS; Single spot, Rf=0.70.
Optical Rotation:
-21.68 (c=0.98, Water)
Sodium Content: 3.61%
Storage and Stability:
May be stored at RT for short-term only. Long-term storage is recommended at -20 degrees C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Hygroscopic. Store under inert atmosphere.
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Toxicity and Hazards:
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