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CLC7, Human (Clcn7, Chloride Channel) Control Peptide

CLC7, Human (Clcn7, Chloride Channel) Control Peptide

Cat no: C5837-56

Supplier: United States Biological
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A 15aa Peptide sequence near the N-terminus of human CLC-7. Chloride is a critical component of all living cells. Voltage-gated chloride channels regulate cellular traffic of chloride ion. The chloride channels (CIC or CLC) performs several functions including the regulation of cell volume, membrane potential stabilization, signal transduction, and transepithelial transport. Mutations in CIC genes have been linked with several human diseases including myotonias (Thomsen's disease), cystic fibrosis, Bartters syndrome type III, Dent's disease, and X-linked recessive nephrolithiasis. In mammals, CLC proteins form a superfamily of at least 9 different genes (CLC1-7 also known as CLCN1-7 and CLK1-2 or CLCKa and CLCKb). Additional forms of these proteins are obtained by alternative splicing. All CLC proteins (~700-1000 aa) are predicted to contain 10 (possibly 12) transmembrane domains. Except CLC-1 and CLC-K1/K2 that are specific for kidney, most other CLC are widely distributed in various tissues. Rat CLC-7 is 802 aa membrane protein (mouse 803 aa, human 805 aa) (1). CLC-7 has a calculated MW of approx. 90kD. CLC-7 is ~45% identical with CLC-6. CLC-7 is expressed in brain, tested, muscle and kidney (1.
Catalogue number: C5837-56
Applications: ELISA, Western Blot
Size: 50ug
Form: Supplied as a liquid in PBS, pH 7.2
Purity: Highly purified
References: 1). Brandt S et al (1995) FEBS Lett. 377, 15-20; Konark U (1998) Gene accession #AF060399; Eggermont J et al (1998) BBA 1397, 156-160; (2) Kornak U et al (2001) Cell 104, 205-215
Additional info: 93% conserved in mouse/rat CLC-7. No significant sequence homology is detected with other CLCs or other proteins

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