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Products Cu/Zn SOD (human) Polyclonal Antibody
| Catalogue number: | 10011388 |
| Hosts: | Rabbit |
| Applications: | Immunohistochemistry, Immunoprecipitation, Western Blot |
| Weight: | 0 |
| Form: | 100 microL |
| Antigen: | human Cu/Zn SOD |
| P type: | Antibodies |
| Purity: | 23 kDa |
| Shipping temp: | -20 |
| Storage temp: | -20 |
| Additional info: | Superoxide dismutase (SOD) is an endogenously produced intracellular enzyme present in almost every cell in the body. It works by catalyzing the dismutation of the superoxide radical O2- to O2 and H2O2, which are then metabolized to H2O and O2 by catalase and glutathione peroxidase. In general, SODs play a major role in antioxidant defense mechanisms. There are two main types of SOD in mammalian cells. One form, SOD1, contains Cu and Zn ions as a homodimer and exists in the cytoplasm. The two subunits of 16 kDa each are linked by two cystines forming an intra-subunit disulphide bridge. The second form, SOD2, is a manganese-containing enzyme and resides in the mitochondrial matrix. It is a homotetramer of 80 kDa. The third form, SOD3 or EC-SOD, is like SOD1 in that it contains Cu and Zn ions, however it is distinct in that it is a homotetramer, with a mass of 30 kDa and it exists only in the extra-cellular space. SOD3 can also be distinguished by its heparin-binding capacity. |
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