Home  >  Products  >  CUDC-101 (7-((4-((3-ethynylphenyl)amino)-7-methoxyquinazolin-6-yl)oxy)-N-hydroxyheptanamide)

CUDC-101 (7-((4-((3-ethynylphenyl)amino)-7-methoxyquinazolin-6-yl)oxy)-N-hydroxyheptanamide)

Cat no: 167798


Supplier: United States Biological
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A potent multitargeted inhibitor of histone deacetylase (HDAC) and the receptor kinases epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2), with IC?? values of 4.4, 2.4, and 15.7nm, respectively. Displays potent antiproliferative and proapoptotic activities against cultured and implanted tumor cells that are sensitive or resistant to several approved single-targeted drugs. Solubility: DMSO Molecular Weight: ~434.49 Storage and Stability: Lyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with sterile buffer or dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: 167798
Size: 5mg
Form: Supplied as a white solid.
Purity: ~98% (HPLC)
References: 1. Lai, C.-J., et al. (2010). Cancer Res. 70:3647-3656; 2. Cai, X., et al. (2010). J. Med. Chem. 53:2000-2009.

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