Home  >  Products  >  Dasatinib (N-[2-Chloro-6-methylphenyl]-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide, BMS-354825)

Dasatinib (N-[2-Chloro-6-methylphenyl]-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide, BMS-354825)

Cat no: D1079


Supplier: United States Biological
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Dasatinib, also known as BMS-354825, is a cancer drug produced by Bristol-Myers Squibb and sold under the trade name Sprycel. Dasatinib is an oral dual BCR/ABL and Src family tyrosine kinases inhibitor approved for use in patients with chronic myelogenous leukemia (CML) after imatinib treatment and Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL). It is also being assessed for use in metastatic melanoma. Related Substances (HPLC): Any single impurity: (same/less than)0.5% Total Impurities: (same/less than)1.0% Solubility: Insoluble in water and slightly soluble in ethanol and methanol Method for Determining Identity: Proton NMR Spectroscopic Analysis, HPLC Loss on Drying: (same/less than) 0.5% Residue on ignition: (same/less than) 0.2% Heavy Metals: (same/less than) 0.002%
Catalogue number: D1079
Size: 100mg
Form: Supplied as an off-white to pale yellow powder
Purity: ~99%
Alternative names: N-[2-Chloro-6-methylphenyl]-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide
References: US Biological application reference: Benezra, M. et al., (2012) Neoplasia 14: 1132

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