DHEA is a steroid secreted by the adrenal gland with both estrogenic and androgenic properties. It is a negative modulator of GABAA receptors. DHEA inhibits the activity of G6PD (glucose 6-phosphate dehydrogenase) in a dose-dependent manner with EC?? of 4.0um. However, DHEA does not inhibit the enzymatic activity of PGD (6-phosphogluconate dehydrogenase), the second enzyme in the pentose phosphate pathway.
Solubility:
DMSO
Molecular Weight:
~288.43
Storage and Stability:
Lyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with sterile buffer or dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
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