DIAPH2 Peptide

Cat no: BS60413P

Supplier: Bioworld Technology, Inc.

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Additional Information

Dia 1 (also designated p140mDia) and Dia 2 (also designated p134mDia 2), mammalian homologs of the Drosophila diaphanous gene, belong to a family of formin homology (FH) proteins which are characterized by having tandemly aligned FH1 and FH2 domains in their carboxy terminal regions. The amino terminus of inactivated Dia 1 binds to the FH1 and FH2 domains and is activated when GTP-bound Rho disrupts the intramolecular interaction of Dia 1 and converts it to an open conformation. Once activated, Dia 1 co-localizes with Profilin and RhoA in dynamic plasma membrane structures and induces the formation of stress fibers in conjunction with the ROCK-mediated signaling pathway. However, Dia 1 and ROCK activities antagonize each other in order to determine the thickness and density of the stress fibers formed.

Catalogue number:	BS60413P
Applications:	Block/Neutralize/Inhibit
Swiss prot:	O60879
Form:	1 mg/ml in DI water.
Purity:	Synthetic peptide DIAPH2. (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage temp:	Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Alternative names:	Protein diaphanous homolog 2; Diaphanous-related formin-2; DRF2; DIA; Diap2; Dia2; Dia 2
Additional info:	This peptide can be used with studies using BS60413 DIAPH2 pAb.

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DIAPH2 Peptide

Cat no: BS60413P

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