A structural analog of EUK 8 and EUK 134 with significantly reduced activity. Acts as a synthetic catalytic scavenger of reactive oxygen species with superoxide dismutase (SOD) and catalase mimetic activity. Superoxide-mediated reduction of an electron acceptor (i.e., SOD mimetic activity) was inhibited by EUK 118 with an IC50 value of 2.0um.
Solubility:
~20mg/ml (DMSO)
Molecular Weight:
~500.38
Storage and Stability:
Lyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with sterile buffer or dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
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Products ![EUK-118 ((acetato- kO)[[2, 2'- [1, 2- ethanediylbis[(nitrilo- kN)methylidyne]]bis[3, 5- dimethoxyphenolato- kO]](2- )]- manganese)](/system/suppliers/default_product_images/000/000/160/main/US-Biological-Life-Sciences.jpg?1386100414)
