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Galiellalactone

Galiellalactone

Cat no: G1044-62

Supplier: United States Biological
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Galiellalactone was originally isolated from Galiella rufa as a plant growth regulator. Recently it was shown to inhibit IL-6 induced SEAP expression with IC50 values of 250-500nM by blocking the binding of the activated Stat3 dimers to their DNA binding sites without inhibiting the tyrosine and serine phosphorylation of the Stat3 transcription factor. Solubility: Soluble in ethanol, methanol, DMF or DMSO. Storage and Stability: Lyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with ethanol, methanol, DMF or DMSO. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: G1044-62
Size: 500ug
Form: Supplied as a white to light tan powder
Purity: (same/more than)90% by HPLC
References: 1. von Nussbaum, F., et al., Eur. J. Org. Chem. 13: 2783 (2004). 2. Kopcke, B., et al., J. Antibiot. 55: 36 (2002). 3. Johansson, M., et al., J. Antibiot. 55: 663 (2002). 4. Weidler M. et al. FEBS Lett. 484: 1 (2000). 5. Hautzel, R. & Anke, H., Z. Naturforsch. 45c: 1094 (1990).

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