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GANT58 (2,3,4,5-Tetra(4-pyridyl)thiophene; NSC75503)

GANT58 (2,3,4,5-Tetra(4-pyridyl)thiophene; NSC75503)

Cat no: G2008

Supplier: United States Biological
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Cell-permeable. Acts as a blocker of Hedgehog (Hh) pathway downstream of SMO and SUFU causing Gli1 nuclear accumulation. It also targets Gli-mediated gene transactivation (IC50 ~ 5uM in SAG-stimulated Shh-L2 cells) and displays anti-proliferative and antitumor activity in vivo. Storage and Stability: Lyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with DMSO or ethanol. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Reconstituted product is stable for 6 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Protect from light and air.
Catalogue number: G2008
Size: 5mg
Form: Supplied as a yellow solid. Reconstitute with 25mM ethanol or 25mM DMSO.
Purity: ~98% (HPLC)
Alternative names: 2,3,4,5-Tetra(4-pyridyl)thiophene; NSC75503
References: 1. Stanton, B.Z., and Peng, L.F. (2010). Mol. Biosyst. 6, 44-54; Lauth, M., et al. (2007). Proc. Natl. Acad. Sci. USA 104, 8455- 8460.

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