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Geninthiocin (14-Demethylberinamycin)

Geninthiocin (14-Demethylberinamycin)

Cat no: G2024-66

Supplier: United States Biological
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Geninthiocin, a thiopeptide antibiotic isolated from a Streptomyces sp., is a potent activator of the tipA gene, a bacterial transcription regulator involved in multidrug resistance. Geninthiocin displays a 10-fold selectivity for bacteria over mammalian cells lines. Purity: >95% by HPLC Solubility: Soluble in methanol, DMF or DMSO.
Catalogue number: G2024-66
Size: 500ug
Purity: >95% by HPLC
Alternative names: 14-Demethylberinamycin
References: 1. Structural basis for antibiotic recognition by the TipA class of multidrug-resistance transcriptional regulators. Kahmann J.D. et al. EMBO J. 2003, 22, 1824. 2. Microbial metabolites with tipA promoter inducing activity. II. Geninthiocin, a novel thiopeptide produced by Streptomyces sp. DD84. Yun B-S. et al. J. Antibiot. 1994, 47, 969.

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