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Gilvocarcin M (Anandimycin B, Toromycin B, Antibiotic 1072A)

Gilvocarcin M (Anandimycin B, Toromycin B, Antibiotic 1072A)

Cat no: G2034-45

Supplier: United States Biological
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Gilvocarcin M is the minor analogue of a complex of C-glycoside antitumor actives isolated from a Streptomyces sp.. Gilvocarcin M contains a methyl group in the 8-position and is less active than the vinyl analogue (gilvocarcin V), which is thought to act as an inhibitor of human topoisomerase II. Gilvocarcin M displays potent antibacterial, antifungal, antiviral and antitumor activity. Recent research on the gilvocarcins suggests that they act as photoactivated crosslinkers of DNA to histones. Purity: > 95% by HPLC Solubility: Soluble in DMF or DMSO. Moderately soluble in methanol or ethanol. Related to: Chrysomycin A, Chrysomycin B, Gilvocarcin V, O-Deacetyl-ravidomycin
Catalogue number: G2034-45
Size: 500ug
Purity: > 95% by HPLC
Alternative names: Anandimycin B, Toromycin B, Antibiotic 1072A
References: 1. Histone H3 and heat shock protein GRP78 are selectively cross-linked to DNA by photoactivated gilvocarcin V in human fibroblasts. Matsumoto A. & Hanawalt P.C. Cancer Res. 2000, 60, 3921. 2. Antitumor agents from Streptomyces anandii: gilvocarcins V, M and E. Balitz D.M. et al.. J Antibiot. (Tokyo) 1981, 34, 1544-1555.

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