Human Histone Deacetylase 3 (HDAC3) is a member of the class I Histone Deacetylases. HDACs are important enzymes for the transcriptional regulation of gene expression in eukaryotic cells. HDACs catalyze the removal of acetyl groups from lysines near the N-termini of histones. Human HDACs have been implicated in a variety of human diseases such as cardiomyopathy, osteodystrophy, neurodegenerative disorders, aging and cancer. Like other class I and II HDAC members, the activity of HDAC3 is sensitive to HDAC inhibitor Trichostatin A (TSA).
Source:
Recombinant corresponding to human HDAC3 expressed in insect cells.
Molecular Weight:
~51kD
Storage and Stability:
Aliquot to avoid repeated freezing and thawing and store at -70 degrees C. Aliquots are stable for 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap
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