Herbimycin A (Herbimycin, Antibiotic TAN 420F)

Cat no: H2030-35A

Supplier: United States Biological

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Herbimycin A is the major analogue of a complex of benzoquinone ansamycin antibiotics isolated from a Streptomyces hygroscopicus. Herbimycin A inhibits the 90-kD heat-shock protein (Hsp90) which provides essential chaperone support to various signal transduction molecules, including including certain steroid hormone receptors and select kinases. Herbimycin has also been shown to inhibit protein tyrosine kinase and angiogensis. Solubility: Soluble in ethanol, methanol, DMF or DMSO. Storage and Stability: Lyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with ethanol, methanol, DMF or DMSO.. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Reconstituted product is stable for 6 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Related to: Antibiotic TAN 420C, Antibiotic TAN 420E, Geldanamycin, Herbimycin B

Catalogue number:	H2030-35A
Size:	500ug
Form:	Supplied as a yellow lyophillized powder.
Purity:	>99% by HPLC
Alternative names:	Herbimycin, Antibiotic TAN 420F
References:	1. Natural product origins of Hsp90 inhibitors. Uehara Y. Curr. Cancer Drug Targets 2003, 3, 325. 2. Effects of geldanamycin, a heat-shock protein 90-binding agent, on T cell function and T cell nonreceptor protein tyrosine kinases. Yorgin P.D. et al. J. Immunol. 2000, 164, 291.

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Herbimycin A (Herbimycin, Antibiotic TAN 420F)

Cat no: H2030-35A

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