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Human Apoptosis protease activating factor-1 (APAF1) ELISA Kit

Human Apoptosis protease activating factor-1 (APAF1) ELISA Kit

Cat no: KTE62504

Supplier: Abbkine Scientific Co.Ltd.
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Apoptotic peptidase activating factor 1 is a proteincontains several copies of the WD40 repeat domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. The precise mechanism for this reaction is still debated though work published by Guy Salvesen suggests that the apoptosome may induce caspase 9 dimerization and subsequent autocatalysis. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis.Alternative splicing results in several transcript variants encoding different isoforms.
Catalogue number: KTE62504
Reactivities: Human
Applications: ELISA
Size: 48T, 96T, 96T*5, 96T*50
Accession: O14727
Gene: 317
Additional info: Human Apoptosis protease activating factor-1 (APAF1) ELISA Kit has high sensitivity and excellent specificity for detection of Human APAF1. No significant cross-reactivity or interference between Human APAF1 and analogues was observed.

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