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Human Pemphigus Foliaceus antibody (PF-Ab) ELISA Kit

Human Pemphigus Foliaceus antibody (PF-Ab) ELISA Kit

Cat no: KTE62480

Supplier: Abbkine Scientific Co.Ltd.
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Desmoglein 1 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, four desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. The protein encoded by this gene has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus foliaceus.From restriction enzyme analysis, they showed that the order of the DSG genes and their orientation is as follows: 5-prime--DSG1--DSG3--DSG2--3-prime. The desmoglein isoforms are expressed in a stratification-related manner in human epidermis, DSG1 being suprabasally expressed and DSG3 at a lower level, while DSG2 expression is weak and basal.
Catalogue number: KTE62480
Reactivities: Human
Applications: ELISA
Size: 48T, 96T, 96T*5, 96T*50
Additional info: Human Pemphigus Foliaceus antibody (PF-Ab) ELISA Kit has high sensitivity and excellent specificity for detection of Human PF-Ab. No significant cross-reactivity or interference between Human PF-Ab and analogues was observed.

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