Medicyte's upcyte® Hepatocytes are genetically engineered human cell strains, derived from single donor primary cells.
Benefits of upcyte® Hepatocytes at a glance:
• Batch sizes up to 2000 vials per donor
• >90 % plateability
• Different donors available
upcyte® Hepatocytes have been tested at each expansion state for:
• Cell morphology
• Viable recovery (~70% of the original viable cells frozen are recovered after thawing)
• >90 % plateability
• Markers: CK8+, CK18+; HSA+, AAT+, AFP-
• Capacity for glycogen storage (PAS staining)
• Inducible CYP activities
upcyte® Hepatocytes have been tested at later expansion stages:
• Urea secretion (basal and stimulated)
We have demonstrated that upcyte® Hepatocytes show similar sensitivity to hepatotoxins to primary cells. Using upcyte® Hepatocytes during screening phases can exclude compounds at an early stage, which means toxic compounds do not reach animal testing stages. Save lives and money!
Tested Applications:
• CYP Induction
• CYP Inhibition
• Genotoxicity
• Basal toxicity
• Cell-specific toxicity (e. g. compounds requiring drug transporters or metabolism)
• HCV infection and virus replication
In addition to our cryopreserved upcyte® Hepatocytes we offer plated human upcyte® Hepatocytes in 6-well plates, 12-well plates, 24-well plates, 48-well plates and 96-well plates.
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