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Imatinib, Free base

Cat no: 167887


Supplier: United States Biological
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An inhibitor of the bcr-abl tyrosine kinase. It acts by binding to the ATP binding site of bcr-abl. Imatinib also stimulates the entry of the bcr-abl tyrosine kinase into the nucleus, where it cannot perform its anti-apoptopic functions. It inhibits EOL-1 cell viability (IC50=0.5nm), phosphorylation of a fusion protein (IC50=30nm), and viability of BaF3 cells expressing Rhe-PDGFRa in the absence of IL-3 (IC50 =0.17nm). Solubility: DMSO (25mg/ml) EtOH (5mg/ml) Molecular Weight: ~493.6D Storage and stability: May be stored at RT for short-term only. Long-term storage is recommended at -20 degrees C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Catalogue number: 167887
Size: 100ug
Form: Supplied as an off white solid.
Purity: ~99% (HPLC)

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