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Products Leukotriene B4 EIA Kit
| Catalogue number: | 520111 |
| Weight: | 0 |
| Form: | 96 Well |
| P type: | Assay Kits|Leukotrienes|Eicosanoids |
| Shipping temp: | -20 |
| Storage temp: | -20 |
| Additional info: | Leukotriene B4 (LTB4) is synthesized from arachidonic acid by the combined action of 5-lipoxygenase and LTA4 hydrolase. LTB4 has long been recognized as a potent mediator of inflammation. It stimulates a number of leukocyte functions, including aggregation, stimulation of ion fluxes, enhancement of lysosomal enzyme release, superoxide anion production, chemotaxis, and chemokinesis. In subnanomolar ranges (3.9 x 10^-10 M), LTB4 causes chemotaxis and chemokinesis in human PMNLs. At higher concentrations, (1.0 x 10^-7 M), LTB4 leads to neutrophil aggregation and degranulation as well as superoxide anion production. Plasma levels of LTB4 increase from <100 pg/ml to >100 ng/ml following leukocyte stimulation. LTB4 is metabolized in leukocytes and hepatocytes to less active 20-hydroxy and 20-carboxy LTB4 by NADPH-dependent cytochrome P450 enzymes followed by .beta.-oxidation at the .omega.-end to .omega.-carboxy dinor LTB4 and .omega.-carboxy tetranor LTB3. LTB4 is not excreted in the urine. |
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