MAD2 (I124) Peptide

Cat no: BS9230P

Supplier: Bioworld Technology, Inc.

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Cell cycle progression is subject to arrest at the mitotic spindle assembly checkpoint in response to incorrect spindle fiber assembly. MAD2 (for mitotic arrest-deficient) is a component of the mitotic spindle checkpoint. Cells with mutated MAD2 do not undergo mitotic arrest in response to incorrect spindle fiber assembly, which results in missegregation and eventual cell death. A breast carcinoma cell line with reduced MAD2 expression, T47D, was shown to complete mitosis in the presence of nocodazole, an inhibitor of mitotic spindle assembly. MAD2 is localized to unattached kinetochores during prometaphase and disassociates upon spindle fiber attachment, indicating that MAD2 regulates kinetochore binding to the spindle fibers.

Catalogue number:	BS9230P
Applications:	Block/Neutralize/Inhibit
Swiss prot:	Q13257
Form:	1 mg/ml in DI water.
Purity:	Synthetic peptide MAD2 (I124). (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage temp:	Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Alternative names:	HSMAD2; Human mitotic feedback control protein Madp2 homolog mRNA complete cds; MAD 2; MAD2 like 1; MAD2 mitotic arrest deficient like 1; MAD2B; MAD2L1; Mitotic arrest deficient 2; Mitotic spindle assembly checkpoint protein MAD2A; REV7;
Additional info:	This peptide can be used with studies using BS9230 MAD2 (I124) pAb.

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MAD2 (I124) Peptide

Cat no: BS9230P

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