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Products Methionine Sulfoxide Immunoblotting Kit
| Catalogue number: | 600160 |
| Weight: | 0 |
| Form: | 1 ea |
| P type: | Assay Kits|Antibodies|Small Molecule Detection (Non-EIA) |
| Shipping temp: | -20 |
| Storage temp: | -20 |
| Additional info: | Protein methionine sulfoxide (MetO) is a reversible oxidative modification that occurs by exposure of protein(s) methionine residues to reactive oxygen species (ROS). Methionine oxidation can alter the function(s) of the modified proteins and if not reversed by MetO reductases can be further oxidized to methionine sulfone, an irreversible modification. Methionine oxidation may occur as a by-product of phagocytotic oxidative bursts, normal mitochondrial respiration and may also occur from environmental chemical exposures. The overabundance of methionine sulfoxidation is implicated in age-related diseases. Cellular protein MetO levels may be influenced by the decrease or loss of methionine sulfoxide reductase (MSR) activity or by an overabundance of ROS leading to increased levels of dysfunctional proteins. The Methionine Sulfoxide Polyclonal Antibody provided in this assay kit detected IgG-containing MetO from sera of Alzheimer |
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