Reacts specifically and rapidly with thiols to form mixed disulfides. Used to probe the structures of the ACh receptor channel of the GABA receptor channel and of lactose permease.
Melting Point: 122-124 degrees C
Solubility: DMSO, methanol
Method for determining Identity:
Proton (DMSO-d6) NMR Spectroscopic and Mass Spectrometric Analysis
TLC Conditions:
SiO2; Dichloromethane: Methanol=4:1;. Visualized with AMCS; Single spot; Rf=0.55.
Storage and Stability:
Moisture-sensitive. Some methanethiosulfonates are hygroscopic and all hydrolyze in water, over a period of time, particularly in the presence of nucleophiles. They should be stored in a desiccator at -20 degrees C and warmed up to RT before opening the vial. For maximum results, solutions should be made up immediately prior to use even though solutions in distilled water appear to be stable for hours at 4 degrees C.
Toxicity and Hazards:
Due to the potential danger associated with the use of some of United States Biological biochemicals, all products should be handled by qualified personnel only, trained in laboratory procedures, and familiar with potential hazards. Information is not available on the possible hazards of many experimental compounds. The absence of a warning must not be interpreted as indication of safety. The ultimate responsibility for the proper handling of any and all chemicals lies with the user. All goods sold by United States Biological carry the condition that liability for any injury, loss or damage whatsoever to persons or real property resulting from the handling of the said goods lies with the user. Acceptance of our goods binds the customer to these terms.
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