Home  >  Products  >  PAK4, Active, Recombinant, Human (pak-4, pak 4, Active PAK4, PDK4, human PDK4, active kinase, active kinases, PDK, recombinant PDK4, recombinant PDK, kinase activity assay, protein kinase)

PAK4, Active, Recombinant, Human (pak-4, pak 4, Active PAK4, PDK4, human PDK4, active kinase, active kinases, PDK, recombinant PDK4, recombinant PDK, kinase activity assay, protein kinase)

Cat no: 167933


Supplier: United States Biological
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PAK4 is a recently identified member of the p21-activated kinases (PAKs) which have been implicated in the regulation of cell morphology, motility and transformation. These serine/threonine kinases are activated by and are effectors of small GTPases, cdc 42 and Rac. PAK4 belongs to the Group II PAKs which also includes PAK5 and PAK6 while Group I PAKs comprise of PAK1, PAK2 and PAK3. PAK4 differs from other members of the PAK family both in sequence and function. PAK4 has been shown to regulate cell morphology and cytoskeletal organization in mammalian cells. PAK4 regulates the activity of LIM kinase 1 which in turn phosphorylates Cofilin leading to cytoskeletal changes. PAK4 can protect cells from apoptosis in response to several different types of stimuli by inhibiting the pro-apoptotic proteins Bad and Caspase 8. PAK4 has been shown to associate with and mediate the downstream signaling of the keratinocyte growth factor receptor. In addition, PAK4 interacts with the b5 integrins and regulates cell migration during engagement of the avb5 integrin receptor. Source: Recombinant protein corresponding to human PAK4 expressed in Sf9 insect cells. Molecular Weight: ~90.0kD Biological Activity: 83 nmol phosphate incorporated into the PKB-sub peptide (CKRPRAASFAE) per minute per mg protein at 30 degrees C for 15 minutes using a final concentration of 50uM ATP (0.83 microCi/assay). Storage and Stability: Aliquot to avoid repeated freezing and thawing and store at -70 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: 167933
Size: 5ug
Form: Supplied as a liquid in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol.
Purity: ~95% (SDS-PAGE)

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