The p21-activated kinase (PAK) family of protein kinases has recently attracted considerable attention as an effector of Rho family of small G proteins and as an upstream regulator of MAPK signalling pathways during cellular events such as re-arrangement of the cytoskeleton and apoptosis. PAK7 is a novel human PAK family kinase that contains a CDC42/Rac1 interactive binding (CRIB) motif at the N-terminus and a Ste20-like kinase domain at the C-terminus. PAK7 like the other Paks has been implicated in the regulation of cell morphology, motility and transformation.
Source:
Recombinant protein corresponding to human PAK7 expressed in Sf9 insect cells.
Molecular Weight:
~130.0kD
Biological Activity:
55nmol phosphate incorporated into the Akt substrate peptide (CKRPRAASFAE) per minute per mg protein at 30 degrees C for 15 minutes using a final concentration of 50um ATP (0.83uCi/assay).
Storage and Stability:
Aliquot to avoid repeated freezing and thawing and store at -70 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
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