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Paprotrain ((Z) a-(3-Pyridinylmethylene)-1H-indo le-3-acetonitrile)

Paprotrain ((Z) a-(3-Pyridinylmethylene)-1H-indo le-3-acetonitrile)

Cat no: 167689

Supplier: United States Biological
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Solubility: 100mM in DMSO and 10mM in ethanol Molecular Weight: ~245.28 Biological Activity: Reversible, non-ATP competitive inhibitor of mitotic kinesin-like protein 2 (MKLP-2) (Ki = 3.4um). Inhibits the basal ATPase activity of MKLP-2 (IC50 = 1.35um). Exhibits selectivity for MKLP-2 over 12 other members of the kinesin superfamily, including the closely-related MKLP-1. Cell permeable. Storage and Stability: Lyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Reconstituted product is stable for 6 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: 167689
Size: 10mg
Form: Supplied as a yellow solid.
Purity: ~99%
References: 1. Tcherniuk et al (2010) Relocation of Aurora B and survivin from centromeres to the central spindle impaired by a kinesin-specific MKLP-2 inhibitor. Agnew Chem.Int.Ed.Engl. 49 8228. PMID: 20857469.

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