Calprotectin is a heterodimeric calcium binding protein of the S100 family predominantly found in the cytosolic fraction of neutrophils. It is also found to some extent in monocytes and activated macrophages. Plasma calprotectin (also known as MRP8/14) levels are increased in various inflammatory conditions. The concentration of calprotectin is greater in faeces than in plasma and significantly increased levels are found in patients with bowel inflammation. Measurement of faecal Calprotectin is considered a reliable indicator of inflammation and numerous studies show that while faecal Calprotectin concentrations are significantly elevated in patients with Inflammatory Bowel Disease (IBD), patients suffering from Irritable Bowel Syndrome (IBS) do not have increased Calprotectin levels. Such increased levels are shown to correlate well with both endoscopic and histological assessment of disease activity and Calprotectin can also be used to monitor patients to assess responses to therapy and help predict relapse.
- Based on established lateral flow technology Provides a quantitative measure of Calprotectin in faecal samples but in a rapid test format Simple and rapid extraction and test process Use with a dedicated reader (sold separately) Excellent correlation with the market leading Calprotectin ELISA: uses a consistent cut off value (50ug/g) Measurable range 30-300ug/g