Home  >  Products  >  RSK1, Active, Recombinant, Human (rsk-1, rsk 1, Active RSK1, RSK1, RSK, human RSK1, active kinase, active kinases, recombinant RSK1, recombinant RSK, kinase activity assay, protein kinase)
RSK1, Active, Recombinant, Human (rsk-1, rsk 1, Active RSK1, RSK1, RSK, human RSK1, active kinase, active kinases, recombinant RSK1, recombinant RSK, kinase activity assay, protein kinase)

RSK1, Active, Recombinant, Human (rsk-1, rsk 1, Active RSK1, RSK1, RSK, human RSK1, active kinase, active kinases, recombinant RSK1, recombinant RSK, kinase activity assay, protein kinase)

Cat no: 167956

Supplier: United States Biological
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The RSK (ribosomal S6 kinase) family comprises growth factor-regulated serine/threonine kinases, known also as p90(rsk). RSK1 contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. Moller described the cloning and characterization of 3 genes encoding RSKs, and HU1 cDNA encodes a predicted 735-amino acid protein containing 2 distinct consensus ATP-binding site sequences. Northern blot and RNase protection analyses detected an approximately 3.5-kb HU1 transcript in lymphocytes, skeletal muscle, liver, and adipose tissue. Zeniou determined the expression of the RSK1, RSK2, and RSK3 genes in various human tissues, during mouse embryogenesis, and in mouse brain. RSKs are implicated in the activation of the mitogen-activated kinase (MAPK) cascade and the stimulation of cell proliferation and differentiation. Source: Recombinant protein corresponding to human RSK1 expressed in Sf9 insect cells. Molecular Weight: ~108.0kD Biological Activity: 38nmol phosphate incorporated into S6K substrate peptide minute per mg protein at 30 degrees C for 15 minutes using a final concentration of 50um ATP (0.83uCi/assay). Storage and Stability: Aliquot to avoid repeated freezing and thawing and store at -70 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: 167956
Size: 5ug
Form: Supplied as a liquid in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol.
Purity: ~90% (SDS-PAGE)
References: 1. Moller, D.E.; Xia, C.H.; Tang, W.; Zhu, A.X.; Jakubowski, M.: Human rsk isoforms: cloning and characterization of tissue-specific expression. Am. J. Physiol. 266: C351-C359, 1994. 2. Zeniou, M.; Ding, T.; Trivier, E.; Hanauer, A.: Expression analysis of RSK gene family members: the RSK2 gene, mutated in Coffin-Lowry syndrome, is prominently expressed in brain structures essential for cognitive function and learning. Hum. Molec. Genet. 11: 2929-2940, 2002. 3. Gross, S.D.; Schwab, M.S.; Lewellyn, A.L.; Maller, J.L.: Induction of metaphase arrest in cleaving Xenopus embryos by the protein kinase p90(Rsk). Science 286: 1365-1367, 1999.

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