Home  >  Products  >  Serpin E1/PAI-1, Recombinant, Human, (Plasminogen activator inhibitor 1) (PAI) (PAI-1) (Endothelial plasminogen activator inhibitor) (Serpin E1)

Serpin E1/PAI-1, Recombinant, Human, (Plasminogen activator inhibitor 1) (PAI) (PAI-1) (Endothelial plasminogen activator inhibitor) (Serpin E1)

Cat no: 167960


Supplier: United States Biological
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Serpins are a group of proteins with similar structures that were first identified as a set of proteins able to inhibit proteases. They are the largest and most diverse family of serine protease inhibitors which are involved in a number of fundamental biological processes such as blood coagulation, complement activation, fibrinolysis, angiogenesis, inflammation and tumor suppression and are expressed in a cell-specific manner. Plasminogen activator inhibitor 1, also known as PAI-1, Endothelial plasminogen activator inhibitor, SERPINE1 and PLANH1, is a secreted protein which belongs to the serpin family. SERPINE1 acts as 'bait' for tissue plasminogen activator, urokinase, and protein C. Its rapid interaction with TPA may function as a major control point in the regulation of fibrinolysis. Defects in SERPINE1 are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency) which is characterized by abnormal bleeding due to SERPINE1 defect in the plasma. High concentrations of SERPINE1 have been associated with thrombophilia which is an autosomal dominant disorder in which affected individuals are prone to develop serious spontaneous thrombosis. Source: Recombinant corresponding to human SERPINE 1 expressed in E.coli. Endotoxin: ~0.1EU/ug Storage and Stability: Aliquot to avoid repeated freezing and thawing and store at -70 degrees C. Aliquots are stable for 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: 167960
Size: 10ug
Form: Supplied as lyophilized powder in 20mM HAc-NaAc, 150mM NaCl, pH 4.0. Reconstitute with PBS at 100ug/ml.
Purity: ~95% (HPLC, SDS-PAGE)

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