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Sodium-Iodide Symporter, FP5

Sodium-Iodide Symporter, FP5

Cat no: SMC-391D


Supplier: StressMarq Biosciences Inc.
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Mapped to AA 625-643 of hNIS. Apparent mol. wt of 97kD, non-glycosylated version at 68kD. Other minor bands associated with hNIS at160 kDa, and degradation products at ~30 kDa, and ~15kDa.
Catalogue number: SMC-391D
Reactivities: Human, Mouse, Rat
Hosts: Mouse
Applications: Immunohistochemistry, Western Blot
Size: 100ug
Clone: FP5
Accession: NP_000444.1
Gene: 6528
Swiss prot: Q92911
Dilutions: 1:1000 (WB)
Form: Protein G purified
Storage buffer: PBS pH7.4, 50% glycerol
Concentration: 1mg/mL
Isotype: IgG1 Kappa
Shipping temp: Blue Ice or 4
Storage temp: -20
Research area: Ion Channels
Certificate of analysis: 1 ug/mL of SMC-391 was sufficient for detection of hNIS in 20 ug of transfected COS-7 cell membrane lysate by ECL immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Scientific background: The sodium iodide symporter (NIS) is an ion pump that actively transports iodide across the basolateral membrane into thyroid epithelial cells (1, 2). This is important step in the process of iodide organificaton and the formation of triiodothyronine and
Alternative names: NIS, SLC5A5, solute carrier family 5, Na (+)I(-) cotransporter
References: 1. Dai G., Levy O., Carrasco N. (1996) Nature. 379(6564): 458-460. 2. Snabik P.A., et al. (1997) Endocrin. 138(8): 3555-3558. 3. Dohan O., et al. (2007) Proc Natl Acad Sci USA. 104(51): 20250-20255.
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