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Tubastatin A (n-Hydroxy-4-((2-methyl-3,4-dihydro-1H-pyrido[4,3-b]-indol-5(2H)-yl)methyl)benzamide)

Tubastatin A (n-Hydroxy-4-((2-methyl-3,4-dihydro-1H-pyrido[4,3-b]-indol-5(2H)-yl)methyl)benzamide)

Cat no: 167987

Supplier: United States Biological
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Cell-permeable, A potent and selective HDAC6 (histone deacetylase 6) inhibitor. Displays 1093-fold selectivity over HDAC1 (IC?? values of 15 nM for HDAC6 vs 16.4um for HDAC1). Tubastatin A was substantially more selective than the known HDAC6 inhibitor Tubacin at all isozymes except HDAC8. In addition, it displayed over 1000-fold selectivity against all HDAC isoforms excluding HDAC8, where it displayed 54-fold selectivity. Tubastatin A displayed dose-dependent protection against HCA (homocysteic acid)-induced neuronal cell death starting at 5um with near complete protection at 10um. Solubility: ~90mg/ml (DMSO),
Catalogue number: 167987
Size: 1mg
Form: Supplied as a off-white solid.
Purity: ~98% (HPLC)
References: 1. Butler, K.V., et al. (2010). J. Am. Chem. Soc. 132:10842- 10846.

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