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MAP Kinase Kinase 4, phosphorylated (Ser80) (MAP2K4, MAPKK 4, MKK4, Dual Specificity Mitogen-activated Protein Kinase Kinase 4, JNK-activating Kinase 1, c-Jun N-terminal Kinase Kinase 1, JNKK, JNKK1, MAPK/ERK Kinase 4, MEK 4, MEK4, PRKMK4, SAPK/ERK Kinase

Cat no: M2865-94L

MAP Kinase Kinase 4, phosphorylated (Ser80) (MAP2K4, MAPKK 4, MKK4, Dual Specificity Mitogen-activated Protein Kinase Kinase 4, JNK-activating Kinase 1, c-Jun N-terminal Kinase Kinase 1, JNKK, JNKK1, MAPK/ERK Kinase 4, MEK 4, MEK4, PRKMK4, SAPK/ERK Kinase

SAPK/Erk kinase (SEK1), also known as MKK4 or Jun kinase kinase (JNKK), activates the MAP kinase homologues SAPK and JNK in response to various cellular stresses and inflammatory cytokines. Activation of SEK1 occurs through phosphorylation of serine and threonine residues at positions 257 and 261, respectively, by MEKK. Like MEK, SEK is a dual-specificity protein kinase that phosphorylates SAPK/JNK at a conserved T*PY* site in its activation loop. Phosphorylation by Akt at Ser80 inhibits SEK1 and suppresses the stress-activated signal transduction.\n\nApplications:\nSuitable for use in Western Blot. Other applications not tested.\n\nRecommended Dilution:\nWestern Blot: 1-4ug/ml\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

M2865-94L

Size

100ug

Applications

WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

Supplied as a liquid in PBS, 1% BSA, 0.02% thimerosal, 50% glycerol.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

Additional Info

Recognizes human MAP2K4 when phosphorylated at Ser80. Species Crossreactivity: Mouse and rat.

Alternative Names

EC=2.7.12.2

Read more on Supplier website

Applications

ELISA

Reactivities

Hum

More info

Applications

IF

Hosts

Mouse

More info

Applications

ELISA, WB

Hosts

Mouse

Reactivities

Hum

More info

Applications

ELISA, FC, WB

Hosts

Mouse

Reactivities

Hum

More info

Applications

ELISA, FC, IHC, WB

Hosts

Mouse

More info

Applications

IHC, WB

Hosts

Rabbit

Reactivities

Hum

More info

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Hum

More info

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